Are There Any SAM e Side Effects?
Good news! SAM e side effects are very few. One reason this is that SAM-e is a natural molecule in your body, and a SAM-e supplement simply replenishes your body’s own natural supply. (SAM e, when taken in proper doses, works faster than antidepressants - usually only two weeks compared to the four week standard for antidepressants. This is one reason why taking SAM e for depression is becoming more and more common.
However, SAM e side effects can occur when you take more SAM e for depression than you should! High doses can lead to SAM-e side effects of anxiety and restlessness, headache, and cause insomnia.
A few people taking high doses have reported SAM e side effect such as mild gas (such as stomach pain, diarrhea, nausea and flatulence), anxiety, insomnia, hyperactive muscle movement, and hypomania. However, many of these symptoms will diminish with time, with lower dosages, or when supplementation is stopped.
Another SAM-e side effect is nausea which can be reduced when it is taken with or after a meal as opposed to an empty stomach.
If you are suffering from severe depression, you should seek advice from a doctor before taking any SAM-e for depression.
SAM e side effects may also include a manic swing if you have bipolar disorder .
How Much SAM e Should You Take?
You can increase the effectiveness and cut down on SAM e side effects by taking 50 or 100 mg SAM-e (one quarter or one half of a 200 mg pill) per day or every other day.
WARNING ON SAM E SIDE EFFECTS
Doctors don’t recommend combining SAM-e with pharmaceutical antidepressants or other drugs and supplements with a stimulant nature.
One reader wrote to Dr. Ray Sahelian, author of Mind Boosters…
Where Can You Get SAM e For Depression?
Ask your doctor before taking SAM e. If you are taking it and are experience SAM e side effects, visit your doctor again!
There is hope! You are worth it!
Almasio P, Bortolini M, et al. Role of S-adenosyl-l-methionine in the treatment of intrahepatic cholestasis. Drugs. 1990; 40 (Suppl 3):111-123.Angelico M, Gandin C, Nistri A, et al. Oral S-adenosyl-L-methionine (SAMe) administration enhances bile salt conjugation with taurine in patients with liver cirrhosis. Scand J Clin Lab Invest 1994;54:459-464.Bell KM, Plon L, Bunney Jr. WE, Potkin SG. S-adenosylmethionine treatment of depression: a controlled clinical trial. Am J Psychiatry. 1988; 145:1110-1113.Bombardieri G, Milani A, Bernardi L, Rossi L. Effects of S-adenosyl-L-methionine (SAMe) in the treatment of Gilbert's syndrome. Curr Ther Res 1985;37:580-585.Bottiglieri T, Godfrey P, et al. Cerebrospinal fluid S-adenosylmethionine in depression and dementia: effects of treatment with parenteral and oral S-adenosylmethionine. J Neuro Neurosurg Psych. 1990; 53:1096-1098.Caruso I, Pietrogrande V. Italian double-blind multicenter study comparing S-adenosylmethionine, naproxen, and placebo in the treatment of degenerative joint disease. Am J Med 1987;83(suppl 5A):66-71.Chawla RK, Bonkovsky HL, Galambos JT. Biochemistry and pharmacology of S-adenosyl-l-methionine and rationale for its use in liver disease. Drugs. 1990; 40 (Suppl 3): 98-110.Frezza M, Surrenti C, Manzillo G, et al. Oral S-adenosyl-methionine in the symptomatic treatment of intrahepatic cholestasis: a double-blind, placebo-controlled study. Gastroenterology 1990;99:211-205.Glorioso S, Todesco S, Mazzi A, et al. Double-blind multicentre study of the activity of S-adenosylmethionine in hip and knee osteoarthritis. Int J Clin Pharmacol Res 1985;5:39-49.Harmand MF, Vilamitjana J, Maloche E, et al. Effects of S-adenosylmethionine on human articular chondrocyte differentiation: an in vitro study. Am J Med 1987;83(suppl 5A):48-54.Jacobsen S, Danneskiold-Samsoe B, Bach Andersen R. Oral S-adenosylmethionine in primary fibromyalgia. Double-blind clinical evaluation. Scan J Rheumatol. 1991; 20:294-302.Kaye GL, Blake JC, Burroughs AK. Metabolism of exogenous S-adenosyl-L-methionine in patients with liver disease. Drugs. 1990; 40 (Suppl 3):124-128.Konig B. Long-term (two year) clinical trial with S-adenosylmethionine for the treatment of osteoarthritis. Am J Med. 1987; 83 (Suppl 5A):89-94.Maccagno A. Double-blind controlled clinical trial of oral S-adenosylmethionine versus piroxicam in knee osteoarthritis. Am J Med 1987;83(suppl 5A):72-77.Marcolongo R, Giordano N, Colombo B, et al. Double-blind multicentre study of the activity of s-adenosyl-methionine in hip and knee osteoarthritis. Curr Ther Res 1985;37:82-94.Muller-Fassbender H. Double-blind clinical trial of S-adenosylmethionine versus ibuprofen in the treatment of osteoarthritis. Am J Med. 1987; (Suppl 5A):81-83.Vetter G. Double-blind comparative clinical trial with S-adenosylmethionine and indomethacin in the treatment of osteoarthritis. Am J Med 1987;83(suppl 5A):78-80.